01
Who we are
Karalis-AI is a biotech startup based in Cagliari, Italy, advancing antimicrobial discovery through AI, molecular modeling, and biophysics.
We combine mechanistic modeling and pretrained neural networks to capture the real biological barriers that determine drug success.
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Our mission
To accelerate the development of effective antimicrobials and beyond by creating predictive, scalable, and biology-aware AI tools that model real-world biomembrane barriers.
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Scientific roots
We bring 20+ years of AMR research leadership across major EU programs, expertise in molecular dynamics, docking and biophysics, Gram-negative permeability, antimicrobial peptides, and siderophore transport.
01
Who we are
Karalis-AI is a biotech startup based in Cagliari, Italy, advancing antimicrobial discovery through AI, molecular modeling, and biophysics.
We combine mechanistic modeling and pretrained neural networks to capture the real biological barriers that determine drug success.
03
Scientific roots
We bring 20+ years of AMR research leadership across major EU programs, expertise in molecular dynamics, docking and biophysics, Gram-negative permeability, antimicrobial peptides, and siderophore transport.
02
Our mission
To accelerate the development of effective antimicrobials and beyond by creating predictive, scalable, and biology-aware AI tools that model real-world biomembrane barriers.
Our Story
From an idea to protecting the future of medicine
01
Beyond AMR
Karalis AIwas founded to tackle the urgent challenge of antimicrobial resistance (AMR). From the start, we saw the need formechanistically informed, biologically validatedpredictive models, leading us to developSMILES and NMR autoencoders—powerful pretrained neural networks with applications far beyond AMR.
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Platform Versatility
These models make our platformversatile: the same AI that predicts drug permeability in Gram-negative bacteria can adapt to new molecules, datasets, and biotech challenges. This positions us not only as an AMR innovator, but as atrusted biotech partner across domains.
Cagliari: Home for Science & Talent
Karalis-AI was born as a university spin-off, rooted in academic excellence and surrounded by one of the richest scientific environments in Italy.
Connected to the Next Generation
We stay connected to the next generation of brilliant researchers.
From Ideas to Innovation
Through theses, projects, and joint programs, we work with top young talent to turn fresh ideas into real innovation.
Academic Advantage
Access to cutting-edge research, highly skilled students, and an inspiring environment where scientific rigor meets entrepreneurial focus.
Team
Meet the minds behind it all